Issue |
Apidologie
Volume 26, Number 2, 1995
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Page(s) | 73 - 81 | |
DOI | https://doi.org/10.1051/apido:19950201 |
DOI: 10.1051/apido:19950201
Influence of cinnamic acid on lymphocyte proliferation, cytokine release and Klebsiella infection in mice
N. Ivanovskaa, H. Neycheva, Z. Stefanovaa, V. Bankovab and S. Popovba Bulgarian Academy of Sciences, Institute of Microbiology, 26, G Bonchev St, 1113 Sofia, Bulgaria
b Bulgarian Academy of Sciences, Institute of Organic Chemistry, 26, G Bonchev St, 1113 Sofia, Bulgaria
Abstract - The effect of a complex of propolis constituents, cinnamic acid and L-lysine, on host defence mechanisms was investigated. After intraperitoneal (ip) application of cinnamic acid lysine complex (CN·Ly) to mice at a dose of 3 mg/kg for 3 consecutive days prior to inoculation with Klebsiella pneumoniae, a protective effect was observed. The action of CN·Ly was associated with its ability to provoke proliferation of thymic and splenic lymphocytes and to augment mitogen-induced proliferation, and the release of interleukin-1 (IL-1) and interleukin-2 (IL-2). In all experiments, a solution of L-lysine in a concentration equivalent to the lysine content in the complex was used for comparison. The results indicated that free lysine acted in a mitogen-like manner predominantly on T-lymphocytes. In the complex, lysine played the role of a carrier and exhibited a less pronounced effect.
Key words: propolis / cinnamic acid / cytokine release / Klebsiella infection