Open Access
Volume 41, Number 3, May-June 2010
Honey bee health
Page(s) 364 - 374
Published online 16 June 2010
  • Anderson D.L., Giacon H. (1992) Reduced pollen collection by honey bee (Hymenoptera: Apidae) colonies infected with Nosema apis and sacbrood virus, J. Econ. Entomol. 85, 47–51.
  • Bailey L. (1981) Honey bee pathology, Academic Press, London, UK, 124 p.
  • Bailey L., Ball B.V. (1991) Honey bee pathology, Academic Press, London, 2nd ed.
  • Chen Y.P., Evans J.D., Smith J.B., Pettis J.S. (2007) Nosema ceranae is a long-present and wide-spread microsporidian infection of the European honey bee (Apis mellifera) in the United States, J. Invertebr. Pathol. 92, 152–159. [CrossRef] [PubMed]
  • Chen Y.P., Evans J.D., Murphy C.A., Gutell R., Zuker M., Gundersen-Rindal, D.E., Pettis, J.S. (2009a) Morphological, molecular, and phylogenetic characterization of Nosema ceranae, a microsporidian parasite isolated from the European honey bee, Apis mellifera, J. Euk. Microb. 56, 142–147. [CrossRef]
  • Chen Y.P., Evans J.D., Zhou L., Boncristiani H., Kimura K., Xiao T.G., Litkowski A.M., Pettis J.S. (2009b) Asymmetrical coexistence of Nosema ceranae and N. apis in honey bees, J. Invertebr. Pathol. 101, 204–209. [CrossRef] [PubMed]
  • Cornman R.S., Chen Y.P., Schatz M.C., Street C., Zhao Y., Desany B., Egholm M., Hutchison S., Pettis J.S., Lipkin W.I., Evans J.D. (2009) Genomic analyses of the microsporidian Nosema ceranae, an emergent pathogen of honey bees, PLoS Pathol. 5, e100466.
  • Cox-Foster D.L., Conlan S., Holmes E., Palacios G., Evans J.D., Moran N.A., Quan P.L., Briese T., Hornig M., Geiser D.M., Martinson V., van Engelsdorp D., Kalkstein A.L., Drysdale A., Hui J., Zhai J., Cui L., Hutchison S.K., Simons J.F., Egholm M., Pettis J.S., Lipkin W.I. (2007) A metagenomic survey of microbes in honey bee colony collapse disorder, Science 318, 283–287. [CrossRef] [PubMed]
  • de Graaf D.C., Jacobs E.J. (1991) Tissue specificity of Nosema apis, J. Invertebr. Pathol. 58, 277–278. [CrossRef]
  • de Graaf D.C., Raes H., Sabbe G., de Rycke P.H., Jacobs F.J. (1994) Early development of Nosema apis (Microspora : Nosematidae) in the midgut epithelium of the honey bee (Apis mellifera), J. Invertebr. Pathol. 63, 74–81. [CrossRef]
  • Fries I. (1989) Observation on the development and transmission of Nosema apis Z. in the ventriculus of the honey bee, J. Apic. Res. 28, 107–117.
  • Fries I. (2010) Nosema ceranae in European honey bees (Apis mellifera), J. Invertebr. Pathol. 103, S73–S79. [CrossRef] [PubMed]
  • Fries I., Feng F. (1995) Crossinfectivity of Nosema apis in Apis mellifera and Apiscerana. In: Proceedings of the Apimondia 34th International Apicultural Congress, Bucharest, Romania, pp. 151–155.
  • Fries I., Feng F., Silva A.D., Slemenda S.B., Pieniazek, N.J. (1996) Nosema ceranae n. sp. (Microspora, Nosematidae), morphological and molecular characterization of a microsporidian parasite of the Asian honey bee Apis cerana (Hymenoptera, Apidae), Eur. J. Protistol. 32, 356–365.
  • Fries I., Martín R., Meana A., García-Palencia P., Higes M. (2006) Natural infections of Nosema ceranae in European honey bees, J. Apic. Res. 45, 230–233. [CrossRef]
  • Gatehouse H.S., Malone L.A. (1998) The ribosomal RNA gene region of Nosema apis (Microspora): DNA sequence for small and large subunit rRNA genes and evidence of a large tandem repeat unit size, J. Invertebr. Pathol. 71, 97–105. [CrossRef] [PubMed]
  • Giersch T., Berg T., Galea F., Hornitzky M. (2009) Nosema ceranae infects honey bees (Apis mellifera) and contaminates honey in Australia, Apidologie 40, 117–123. [CrossRef] [EDP Sciences]
  • Gilliam M., Shimanuki H. (1967) In vitro phagocytosis of Nosema apis spores by honeybee hemocytes, J. Invertebr. Pathol. 9, 387–389. [CrossRef] [PubMed]
  • Goodwin M., Ten Houten A., Perry J., Blackman R. (1990) Cost benefit analysis of using fumagillin to treat Nosema, New Zeal. Beekeeper 208, 11–12.
  • Gutell R.R., Noller H.F., Woese C.R. (1986a) Higher order structure in ribosomal RNA, EMBO J. 5, 1111–1113. [PubMed]
  • Gutell R.R., Weiser B., Woese C.R., Noller H.F. (1986b) Comparative Anatomy of 16S-like ribosomal RNA, Prog. Nucl. Acid Res. Mol. Biol. 32, 155–216. [CrossRef]
  • Hassanein M.H. (1953a) The influence of Nosema apis on the larval honeybee, Ann. Appl. Biol. 38, 844–846. [CrossRef]
  • Hassanein M.H. (1953b) Infection with Nosema apis on the activities and longevity of the worker honeybee, Ann. Appl. Biol. 40, 418–423. [CrossRef]
  • Higes M., García-Palencía P., Martín-Hernández R., Meana A. (2007) Experimental infection of Apis mellifera honeybees with Nosema ceranae (Microsporidia), J. Invertebr. Pathol. 94, 211–217. [CrossRef] [PubMed]
  • Higes M., Martín-Hernández R., Botías C., Bailón E.G., González-Porto A.V., Barrios L., del Nozal M.J., Bernal J.L., Jiménez J.J., Palencia P.G., Meana A. (2008) How natural infection by Nosema ceranae causes honey bee colony collapse, Environ. Microbiol. 10, 2659–2669. [CrossRef] [PubMed]
  • Higes M., Martín R., Meana A. (2006) Nosema ceranae, a new microsporidian parasite in honey bees in Europe, J. Invertebr. Pathol. 92, 93–95. [CrossRef] [PubMed]
  • Huang W.F., Jiang J.H., Chen Y.W., Wang C.H. (2007) A Nosema ceranae isolate from the honeybee Apis mellifera, Apidologie 38, 30–37. [CrossRef] [EDP Sciences]
  • Huang W.F., Jiang J.H., Wang C.H. (2005) Nosema ceranae infection in Apis mellifera. 38th Annual Meeting of Society for Invertebrate Pathology, Anchorage, Alaska.
  • Huang Z.Y. (2001) Honey bee biology laboratory annual report,, (visited Nov. 1, 2009).
  • Klee J., Besana A.M., Genersch E., Gisder S., Nanetti A., Tam D.Q., Chinh T.X., Puerta F., Ruz J.M., Kryger P., Message D., Hatjina F., Korpela S., Fries I., Paxton R.J. (2007) Widespread dispersal of the microsporidian Nosema ceranae, an emergent pathogen of the western honey bee, Apis mellifera, J. Invertebr. Pathol. 96, 1–10. [CrossRef] [PubMed]
  • Larsson R. (1986) Ultrastructure, function, and classification of microsporidia, in: Corliss J.O., Patterson D.J. (Eds.), Progress in protistology, Vol. 1. Biopress, Bristol, England, pp. 325–390.
  • Liu T.P. (1984) Ultrastructure of the midgut of the worker honey Apis mellifera heavily infected with Nosema apis, J. Invertebr. Pathol. 44, 103–105. [CrossRef]
  • Liu F., Wang Q., Dai P.L., Wu Y.Y., Song H.K., Zhou T. (2008) Natural stripe of Microsporidia of honeybee in China, Chinese Bull. Entomol. 45, 963–966.
  • Malone L.A., Giacon H.A., Newton M.R. (1995) Comparison of the responses of some New Zealand and Australian honey bees (Apis mellifera L) to Nosema apis Z., Apidologie 26, 495–502. [CrossRef] [EDP Sciences]
  • Matheson A. (1993) World bee health update, Bee World 74, 176–212.
  • Mayack C., Naug D. (2009) Energetic stress in the honeybee Apis mellifera from Nosema ceranae infection, J. Invertebr. Pathol. 100, 185–188. [CrossRef] [PubMed]
  • Naug D., Gibbs A. (2009) Behavioral changes mediated by hunger in honeybees infected with Nosema ceranae, Apidologie 40, 595–599. [CrossRef] [EDP Sciences]
  • Paxton R.J. (2010) Does infection by Nosema ceranae cause « Colony Collapse Disorder » in honey bees (Apis mellifera)? J. Apic. Res. 49, 80–84. [CrossRef]
  • Paxton R.J., Klee J., Korpela S., Fries I. (2007) Nosema ceranae has infected Apis mellifera in Europe since at least 1998 and may be more virulent than Nosema apis, Apidologie 38, 558–565. [CrossRef] [EDP Sciences]
  • Plischuk S., Martín-Hernández R., Lucía M., Prieto L., Botías C., Meana A., Abrahamovich A.H., Lange C., Higes M. (2009) South American native bumblebees (Hymenoptera: Apidae) infected by Nosema ceranae (Microsporidia), an emerging pathogen of honeybees (Apis mellifera), Environ. Microbiol. Reports 1, 131–135. [CrossRef]
  • Rinderer T.E., Sylvester H.A. (1978) Variation in response to Nosema apis, longevity, and hoarding behavior in a free-mating population of the honey bee, Ann. Entomol. Soc. Am. 71, 372–374.
  • Sokolova Y.Y., Kryukova N.A., Glupov V.V., Fuxa J.R. (2006) Systenostrema alba Larsson 1988 (Microsporidia, Thelohaniidae) in the Dragonfly Aeshna viridis (Odonata, Aeshnidae) from South Siberia: morphology and molecular characterization, J. Euk. Microb. 53, 49–57. [CrossRef]
  • vanEngelsdorp D., Evans J.D., Saegerman C., Mullin C., Haubruge E., Nguyen B.K., Frazier M., Frazier J., Cox-Foster D., Chen Y.P., Underwood R., Tarpy D.R., Pettis J.S. (2009) Colony Collapse Disorder: A Descriptive Study, PLoS ONE 4, e6481. [CrossRef] [PubMed]
  • Wang D., Moeller F. (1970) The division of labor and queen attendance behavior of Nosema-infected worker honeybees, J. Econ. Entomol. 63, 1539–1541.
  • Williams G.R., Shafer A.B.A., Rogers R.E.L., Shutler D., Stewart D.T. (2008) First detection of Nosema ceranae, a microsporidean parasite of European honey bees (Apis mellifera), in Canada and central USA, J. Invertebr. Pathol. 97, 189–192. [CrossRef] [PubMed]
  • Zander E. (1909) Tierische Parasiten als Krankenheitserreger bei der Biene, Münchener Bienenzeitung 31, 196–204.